To summarize the clinical experience of professor Luo Zhijuan in the treatment of premature ovarian insufficiency(POI). It is believed that the main pathogenesis of POI is kidney deficiency. On the basis of “tonifying the kidney”. We advocate the “Rule of Thirds Theory”which is to treat POI according to different stages, menstrual cycles and syndromes, the prescription can be flexibly added or decreased .And make good use of cream prescription, to ping for a period of time, the curative effect is obvious.