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本文应用ABC免疫组织化学方法对49例膀胱移行细胞癌中的纤维粘连蛋白(FN)作了研究。结果发现:FN的分布形式有细胞周、间质及细胞浆三种形式:随着移行细胞癌组织学分级的增高,细胞周FN及间质FN逐渐减少,而胞浆FN则有所增加。结果提示:这些变化可能是膀胱移行细胞癌浸润转移的重要基础;并可能与预后有一定关系。
In this paper, we used ABC immunohistochemistry to study the expression of fibronectin (FN) in 49 cases of transitional cell carcinoma of the bladder. The results showed that there were three forms of FN: pericyte, interstitial and cytoplasm. With the increase of histological grade of transitional cell carcinoma, FN and FN decreased gradually, but FN increased. The results suggest that these changes may be an important basis for invasion and metastasis of transitional cell carcinoma of the bladder, and may have a relationship with the prognosis.