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目的调查滨南油区中老年人群冬季维生素D水平营养状况,为促进中老年人群预防骨质疏松、心血管疾病、糖尿病,提高机体免疫力等身体健康问题提供科学依据。方法采用随机整群抽样方法,收集2015年11月-2016年1月来自建翔医院35~70岁中老年人群并且在本地区居住5年以上的小区居民体检者血液标本475例,测量身高、体重计算出体重指数,腹部肝胆B超记录脂肪肝情况,罗氏Cobas e411电化学发光分析法测定血清总25-羟基维生素D(25OHD)的量,按年龄、性别分层分析本地区中老年人群维生素D营养状况、25OHD在不同脂肪肝中的分布情况及与体重指数的相关性。结果 (1)滨南油区35~70岁中老年人群血清总25OHD平均浓度(12.31±6.54)ng/ml,严重缺乏、缺乏、不足和充足分别占45.0%、39.8%、14.1%和1.1%。(2)男性25OHD水平明显高于女性,差异有统计学意义(t=11.524,P<0.05)。女性缺乏率(96.0%)明显高于男性(72.3%),差异有统计学意义(χ2=51.674,P<0.05)。(3)各年龄段血清25OHD值差异无统计学意义(F=2.572,P>0.05)。男性组各年龄段血清25OHD值差异无统计学意义(F=0.642,P>0.05)。女性46~55岁组25OHD值较35~45岁组和56~70岁明显偏低,差异有统计学意义(P<0.05)。(4)25OHD在脂肪肝中的分布差异无统计学意义(F=0.196,P>0.05)。超重组25OHD值较非超重组明显低,差异有统计学意义(t=4.309,P<0.05),并且25OHD与体重指数间有明显的相关性(r=0.114,P<0.05)。结论滨南油区35~70岁中老年人群冬季存在较严重的25OHD缺乏状况,25OHD营养状况男性优于女性,46~55岁更年期女性维生素D水平更低,超重者比非超重者有较低的维生素D水平。
Objective To investigate the nutritional status of winter vitamin D in middle-aged and elderly people in Binnan Oil Region and provide a scientific basis for the prevention of osteoporosis, cardiovascular diseases, diabetes mellitus and the improvement of body immunity in middle-aged and elderly people. Methods Randomized cluster sampling was used to collect 475 blood samples from community residents from 35 to 70 years old in Jianxiang Hospital who lived in the region for more than 5 years from November 2015 to January 2016. The blood samples of height, BMI was calculated by weight, and fatty liver was diagnosed by B-ultrasonography in abdominal hepatobiliary. Roche Cobas e411 electrochemiluminescence assay was used to determine the amount of 25-hydroxyvitamin D (25OHD) in serum. Hierarchical analysis of vitamins D nutrition status, the distribution of 25OHD in different fatty liver and the correlation with body mass index. Results (1) The average serum 25OHD level of middle-aged and elderly people aged 35-70 years in Binan Oil Region was (12.31 ± 6.54) ng / ml. The serious lack, deficiency, deficiency and deficiency accounted for 45.0%, 39.8%, 14.1% and 1.1% . (2) The level of 25OHD in males was significantly higher than that in females, the difference was statistically significant (t = 11.524, P <0.05). The rate of female deficiency was significantly higher (96.0%) than that of men (72.3%) (χ2 = 51.674, P <0.05). (3) There was no significant difference in serum 25OHD values among all age groups (F = 2.572, P> 0.05). There was no significant difference in serum 25OHD between men and women in all ages (F = 0.642, P> 0.05). The 25OHD values of 46-55 years old women were significantly lower than those of 35-45 years old women and 56-70 years old women (P <0.05). (4) There was no significant difference in the distribution of 25OHD in fatty liver (F = 0.196, P> 0.05). The 25OHD value in overweight group was significantly lower than that in non - overweight group (t = 4.309, P <0.05), and there was a significant correlation between 25OHD and body mass index (r = 0.114, P <0.05). Conclusion The prevalence of 25OHD in the middle aged and aged population of 35 ~ 70 years old in Binan Oil Region is more severe in winter, and the nutritional status of 25OHD is better than that of female. The vitamin D level of 46-55 years old menopausal women is lower than that of non-overweight Vitamin D levels.