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目的观察疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期(AECOPD)轻中度患者的临床疗效。方法选取2012年9月—2014年10月亳州市华佗中医院收治的AECOPD轻中度患者120例,按入院时间分为治疗组与对照组,各60例。对照组患者给予常规治疗,治疗组患者在对照组基础上给予疏风解毒胶囊治疗,两组患者疗程均为1周。比较两组患者治疗前后动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2),治疗1周后临床疗效及治疗期间抗生素使用情况、不良反应发生情况。结果意向性治疗(ITT)分析及符合方案(PP)分析显示,两组患者治疗前Pa O2、Pa CO2比较,差异均无统计学意义(P>0.05);治疗组患者治疗后Pa O2均高于对照组,Pa CO2均低于对照组(P<0.05);两组患者治疗后Pa O2均高于治疗前,Pa CO2均低于治疗前(P<0.05)。治疗组患者治疗期间抗生素使用率低于对照组(P<0.05)。ITT分析及PP分析结果显示,治疗组患者的临床疗效均优于对照组(u值分别为2.174、2.092,P<0.05)。两组患者治疗期间均未见明显肝肾功能异常、皮肤瘙痒、心悸等。结论疏风解毒胶囊治疗AECOPD轻中度患者的临床疗效确切,有利于促进肺功能恢复及减少抗生素的使用。
Objective To observe the clinical efficacy of Shufeng Jiedu Capsule in the treatment of mild to moderate chronic obstructive pulmonary disease (AECOPD). Methods A total of 120 mild and moderate AECOPD patients admitted to Huaqiao Hospital of Traditional Chinese Medicine from September 2012 to October 2014 were selected and divided into treatment group and control group according to the time of admission. Patients in the control group were given routine treatment. Patients in the treatment group were treated with Shufeng Jiedu Capsule on the basis of the control group, and both groups were treated for one week. The PaO 2 and PaCO 2 were compared between the two groups before and after treatment. The clinical efficacy, antibiotic use and adverse reactions after 1 week of treatment were compared. Results Intent-to-Treatment (ITT) analysis and PP analysis showed that there was no significant difference in PaO2 and Pa2CO between the two groups before treatment (P> 0.05). The PaO2 in the treatment group was significantly higher after treatment PaCO 2 in the control group was lower than that in the control group (P <0.05). The PaO 2 in both groups was significantly higher than that before treatment, PaCO 2 was lower than before treatment (P <0.05). The antibiotic use rate in the treatment group was lower than that in the control group (P <0.05). ITT analysis and PP analysis showed that the clinical efficacy of the treatment group were better than the control group (u values were 2.174,2.092, P <0.05). No significant liver and kidney dysfunction, pruritus and heart palpitations were found in the two groups during treatment. Conclusion Shufeng Jiedu capsule treatment of patients with mild to moderate AECOPD clinical curative effect is exact, is conducive to promoting pulmonary function recovery and reduce the use of antibiotics.