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目的:探讨进展期胃癌术后早期腹腔化疗的疗效及毒副反应。方法:将64例进展期胃癌分为两组,治疗组32例手术后早期行腹腔化疗加全身静脉化疗,对照组术后行单纯静脉化疗。结果:治疗组3 a、5 a生存率均高于对照组,差异有显著性(P<0.05)。治疗组12例发生腹痛、腹胀,经对症处理后好转。结论:术后早期腹腔化疗能提高进展期胃癌生存率,局部区域性毒副作用可耐受,可广泛应用于临床。
Objective: To investigate the curative effect and toxicity of early postoperative chemotherapy for advanced gastric cancer. Methods: 64 cases of advanced gastric cancer were divided into two groups. In the treatment group, 32 cases were treated with intraperitoneal chemotherapy and systemic intravenous chemotherapy in the early postoperative period, while those in the control group were treated with simple intravenous chemotherapy. Results: The survival rates at 3 and 5 years in the treatment group were significantly higher than those in the control group (P <0.05). In the treatment group, abdominal pain and bloating occurred in 12 patients, which improved after symptomatic treatment. Conclusion: Early postoperative intraperitoneal chemotherapy can improve the survival rate of advanced gastric cancer, local regional side effects can be tolerated, and can be widely used in clinical practice.