论文部分内容阅读
目的:通过比较缺血性脑卒中患者与健康体检者的牙周状况和血清炎症标志物水平,探讨牙周炎与缺血性脑卒中的相关性。方法:选择60例缺血性脑卒中患者和同样数量的健康体检者,由同一名医师进行牙周检查,并采集入选者的血清检测其超敏C-反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)水平,进行统计学分析和比较。结果:缺血性脑卒中组与健康体检者间的牙周炎患病率、重度缺牙(缺牙数≥10个)率和牙周指数均存在显著性差异(P<0.01),两组间血清hs-CRP、IL-1β水平也有显著性差异(P<0.01),但TNF-α含量无统计学差异。结论:牙周炎与缺血性脑卒中有较密切相关性,重度缺牙是动脉粥样硬化与缺血性脑卒中的重要危险指征。hs-CRP、IL-1β可能与牙周炎和缺血性脑卒中的发病机制有关联。
OBJECTIVE: To investigate the relationship between periodontitis and ischemic stroke by comparing the periodontal status and serum levels of inflammatory markers in patients with ischemic stroke and healthy subjects. Methods: Sixty patients with ischemic stroke and the same number of healthy subjects were selected for the periodontal examinations by the same physician. Serum samples were collected for detection of hs-CRP, 1β (IL-1β) and tumor necrosis factor-α (TNF-α) were measured and compared statistically. Results: The prevalence of periodontitis, the number of severe edentulous teeth (≥10 teeth missing) and periodontal index in ischemic stroke group and healthy volunteers were significantly different (P <0.01). Two groups Serum hs-CRP, IL-1β levels were also significantly different (P <0.01), but there was no significant difference in TNF-α content. Conclusion: There is a close relationship between periodontitis and ischemic stroke. Severe tooth loss is an important risk indicator of atherosclerosis and ischemic stroke. hs-CRP, IL-1β may be related to the pathogenesis of periodontitis and ischemic stroke.