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帕金森氏症(Parkinson’s disease,PD)是以黑质纹状体通路受损、纹状体多巴胺(DA)含量减少为主要病理特征的一种神经系统疾病。以往对PD的病理过程研究主要是在患者死后进行的,因此患者生前的病理资料很难得到。最近,正电子发射断层扫描技术在PD病理研究中的应用,在很大程度上弥补了上述缺陷。正电子发射断层扫描(positron emission tomography,PET)是一种新的核医学影像技术,其原理是将标记正电子发射的同位素药物注入机体,通过断层扫描观察药物在生物体内某些部位的分布和代谢,以此定量测定脑的血流动力学.代谢、受体药理学和神经递质的代谢状况。它的优点是可以同时兼顾形态学与机能学的观察。
Parkinson’s disease (PD) is a kind of neurological disease that is impaired by the nigrostriatal pathway and reduced in striatum dopamine (DA) as the main pathological features. In the past the pathological process of PD is mainly after the death of the patient, so the pathological data of patients before birth is difficult to get. Recently, the application of positron emission tomography in PD pathology has largely remedied the above drawbacks. Positron emission tomography (PET) is a new nuclear medicine imaging technology. Its principle is to inject the labeled positron emitting isotope drug into the body and to observe the distribution of the drug in some parts of the body through the tomography Metabolism, in order to quantify brain hemodynamics Metabolism, receptor pharmacology and neurotransmitter metabolic status. Its advantage is that it can take both morphological and functional observation.