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业已证明脉冲式给予LHRH治疗促性腺激素低下男子可以刺激垂体性腺轴。目前许多研究目的是确定合适的LHRH剂量。本研究以正常健康男子单次静注LHRH后的LHRH和LH水平来探索治疗促性腺激素低下病人最佳的LHRH剂量。研究包括26例健康男子,年龄25.9±5.2岁。性发育和性功能正常,无明显内分泌紊乱,随机分为4个剂量组:(1)LHRH20μg,5例,(2)LHRH 5μg 5例,(3)LHRH 2.5μg 8例,(4)LHRH 1μg 8例。平均体重分别为76.2±6.9,77.2±7.4,75.4±9.3和75.3±6.2kg,
It has been demonstrated that pulsed administration of LHRH to gonadotropin-lowering men stimulates the pituitary gland axis. At present, many studies aim to determine the appropriate LHRH dose. In this study, the LHRH and LH levels of LHRH after a single intravenous injection in normal healthy men were explored to find the best LHRH dose for patients with low gonadotropin. The study included 26 healthy men, aged 25.9 ± 5.2 years. (1) LHRH 20μg, 5 cases, (2) LHRH 5μg 5 cases, (3) LHRH 2.5μg 8 cases, (4) LHRH 1μg 8 cases. The average body weights were 76.2 ± 6.9, 77.2 ± 7.4, 75.4 ± 9.3 and 75.3 ± 6.2 kg, respectively,