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目的探讨头孢哌酮联合舒巴坦治疗肾盂肾炎的疗效。方法将2011年1月至2013年1月期间收治的120例肾盂肾炎患者随机分为对照组与观察组,每组60例。对照组采用左氧氟沙星治疗,观察组采用头孢哌酮联合舒巴坦治疗。治疗15 d后分别观察两组患者总治疗有效率及治疗前后患者肝肾功能变化情况。结果观察组总治疗有效率为96.67%,对照组为81.67%,两组比较差异有统计学意义(χ2=6.986,P<0.05)。治疗后两组患者肝肾功能均有明显改变,且观察组肝肾功能各项观察指标改善程度明显大于对照组,两组比较差异有统计学意义(χ2=6.325,P<0.05)。结论头孢哌酮联合舒巴坦治疗肾盂肾炎效果显著,不良反应小,值得临床推广。
Objective To investigate the efficacy of cefoperazone combined with sulbactam in the treatment of pyelonephritis. Methods 120 patients with pyelonephritis admitted from January 2011 to January 2013 were randomly divided into control group and observation group, with 60 cases in each group. The control group was treated with levofloxacin, and the observation group was treated with cefoperazone and sulbactam. After 15 days of treatment, the total effective rate of treatment and the change of liver and kidney function in both groups were observed before and after treatment. Results The total effective rate was 96.67% in the observation group and 81.67% in the control group. The difference between the two groups was statistically significant (χ2 = 6.986, P <0.05). After treatment, the liver and kidney function of the two groups were significantly changed, and the observation group liver and kidney function improved significantly more than the control group, the difference between the two groups was statistically significant (χ2 = 6.325, P <0.05). Conclusion Cefoperazone combined with sulbactam has a significant effect in treating pyelonephritis and its adverse reaction is small, which is worthy of clinical promotion.