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2002与2003年之交,由SARS冠状病毒引起的疾病流行是近期非常著名的一次公共卫生事件。而正在流行的中东呼吸系统综合征冠状病毒感染提示,这类病毒仍然存在威胁,而且其分布范围比此前认识的要宽。虽然蝙蝠被认为是这两种病毒的天然宿主,但从蝙蝠身上分离SARS冠状病毒的前体病毒的目标一直没有取得成功。目前,在中国、欧洲和非洲的蝙蝠身上也分离出多种SARS样冠状病毒(SLCoVs),但没有一种被认为是SARS冠状病毒的直接前体,这是因为它们与SARS冠状病毒存在系统发育上的差异,它们的突起蛋白不能利用SARS冠状病毒的细胞受体——人血管紧张素转换酶II(ACE2)。
Between 2002 and 2003, the SARS-Co-infected disease epidemic was a very well-known recent public health event. The prevalence of SARS-CoV infection suggests that these types of viruses are still at risk and their distribution is broader than previously thought. Although bats are thought to be natural hosts for both viruses, the goal of isolating the SARS-CoV precursor virus from bats has been unsuccessful. Currently, many species of SARS-like coronavirus (SLCoVs) are also isolated from bats in China, Europe and Africa, but none is considered a direct precursor to the SARS coronavirus because of its phylogenetic relationship with the SARS coronavirus On the other hand, their raised proteins do not utilize the cellular receptor for human SARS-CoV, human angiotensin-converting enzyme II (ACE2).