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目的探讨宫颈鳞癌组织中转移相关基因1的表达与肿瘤浸润及转移的关系。方法采用免疫组织化学方法检测50例宫颈鳞癌患者宫颈组织中转移相关基因1的表达情况。结果宫颈鳞癌组织中浸润深度>1/2者的转移相关基因1阳性表达明显高于浸润深度≤1/2者,在低分化宫颈鳞癌中转移相关基因1阳性表达明显高于高分化的宫颈鳞癌,有淋巴转移和脉管浸润者转移相关基因1阳性表达明显高于无淋巴转移和脉管浸润者,相比较有统计学差异(P<0.01)。结论转移相关基因1对宫颈鳞癌的浸润及转移发挥着重要作用。
Objective To investigate the relationship between the expression of metastasis-related gene 1 and tumor invasion and metastasis in cervical squamous cell carcinoma. Methods Immunohistochemistry was used to detect the expression of metastasis-related gene 1 in cervical squamous cell carcinoma in 50 cases of cervical squamous cell carcinoma. Results The positive expression of metastasis-associated gene 1 in invasive squamous cell carcinoma was significantly higher than that in invasive depth squamous cell carcinoma (≤1 / 2). The positive expression of metastasis-associated gene 1 in poorly differentiated cervical squamous cell carcinoma was significantly higher than that in well-differentiated Cervical squamous cell carcinoma, lymph node metastasis and vascular invasion metastasis-related gene 1 positive expression was significantly higher than those without lymph node metastasis and vascular invasion, compared with a statistically significant difference (P <0.01). Conclusion Metastasis-related gene 1 plays an important role in the invasion and metastasis of cervical squamous cell carcinoma.