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目的:探讨硫酸镁联合酚妥拉明及硝普钠在治疗重度子痫前期并发左心衰竭中的疗效。方法:收集2008年1月至2015年12月在我院住院的重度子痫合并左心衰竭的患者48例,其中2008年1月至2012年12月收治的24例患者采用单独硫酸镁治疗方法,为对照组,2013年1月至2015年12月收治的24例患者采用硫酸镁联合酚妥拉明及硝普钠的治疗方法,为观察组,并观察两组患者在治疗后的疗效、血气情况及相关检验结果。结果:经过治疗观察组患者较对照组的疗效有明显改善;观察组治疗后心率(HR)、呼吸(RR)、收缩压(SBP)、舒张压(DBP)较对照组显著下降,观察组治疗后Pa CO2、Pa O2、Sa O2较对照组显著上升;观察组治疗后血小板较对照组显著升高,观察组治疗后,丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)、尿素氮、肌酐、尿酸、尿蛋白较对照组显著下降。以上差异均具有统计学意义(P<0.05)。结论:硫酸镁联合酚妥拉明及硝普钠在治疗重度子痫前期并发左心衰竭中治疗具有良好的疗效,能够有效改善患者的血气及相关检验指标情况,具有一定的临床推广价值。
Objective: To investigate the efficacy of magnesium sulfate combined with phentolamine and sodium nitroprusside in the treatment of severe preeclampsia complicated with left heart failure. Methods: Forty-eight patients with severe eclampsia and left heart failure who were hospitalized in our hospital from January 2008 to December 2015 were collected. Among them, 24 patients admitted from January 2008 to December 2012 were treated with magnesium sulfate alone , The control group, 24 patients admitted from January 2013 to December 2015 were treated with magnesium sulfate combined with phentolamine and sodium nitroprusside for the observation group, and observed the therapeutic effect of the two groups of patients after treatment, Blood gas and related test results. Results: After treatment, the curative effect of the observation group was better than that of the control group. The HR, RR, SBP and DBP of the observation group decreased significantly compared with the control group After PaCO 2, Pa 2 O 2 and Sa 2 O, the levels of PaCO 2, PaO 2 and SaO 2 in the observation group increased significantly compared with the control group. After treatment, the levels of ALT, AST, , Creatinine, uric acid, urine protein decreased significantly compared with the control group. The above differences were statistically significant (P <0.05). CONCLUSIONS: Magnesium sulfate combined with phentolamine and sodium nitroprusside have a good curative effect in the treatment of severe preeclampsia complicated with left heart failure, and can effectively improve the blood gas of patients and related test indicators, which has certain clinical value of promotion.