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目的探讨新化合物3-硝基-4-{[4-(2,3,4-三甲氧基苯基)哌嗪-1-基]甲基}-苯甲酰基胍(TG-6)对大鼠心肌缺血-再灌注(I-R)损伤的保护作用。方法结扎大鼠冠状动脉左前降支40 min,再灌注120 min建立心肌I-R损伤模型。48只大鼠分为A组(假手术组)、B组(I-R模型组)、C组(模型组+卡立泊来德1 mg/kg)、D组(模型组+TG-6 1 mg/kg)、E组(模型组+TG-6 0.5 mg/kg)、F组(模型组+TG-6 0.25 mg/kg),每组8只。观察TG-6对大鼠心功能学、心肌梗死面积及血清生化指标的影响。结果与B组比较,D、E、F组左心室内压最大上升与下降速率(±dP/dtmax)、血清超氧化物歧化酶(SOD)活力增高,左心室舒张末期压力(LVEDP)、血清肌酸激酶(CK)活力、乳酸脱氢酶(LDH)活力、丙二醛(MDA)含量降低(P<0.05);D、E组心率、左心室内压(LVSP)增加,心肌梗死面积缩小(P<0.05)。结论 TG-6明显减轻大鼠心肌I-R损伤,有望成为治疗心肌I-R损伤新型药物。
Aim To investigate the effect of the new compound 3-nitro-4 - {[4- (2,3,4-trimethoxyphenyl) piperazin-1-yl] methyl} -benzoylguanidine (TG-6) Protective Effect of Myocardial Ischemia - Reperfusion (IR) Injury in Rats. Methods The left anterior descending coronary artery of rats was ligated for 40 min and reperfused for 120 min to establish myocardial I-R injury model. Forty-eight rats were divided into three groups: sham operation group, sham operation group, IR group, C group (model group + cariporide 1 mg / kg), group D / kg), group E (model group + TG-6 0.5 mg / kg) and group F (model group + TG-6 0.25 mg / kg) The effects of TG-6 on cardiac function, myocardial infarct size and serum biochemical parameters were observed. Results Compared with group B, the maximal increase and decrease of left ventricular pressure (± dP / dtmax), the increase of serum SOD activity, the left ventricular end-diastolic pressure (LVEDP), serum The activities of creatine kinase (CK), lactate dehydrogenase (LDH) and malondialdehyde (MDA) decreased (P <0.05). Heart rate and left ventricular pressure (LVSP) increased and myocardial infarct size decreased (P <0.05). Conclusion TG-6 significantly attenuates I-R injury in rat myocardium and is expected to become a new drug for the treatment of myocardial I-R injury.