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目的探讨宫颈癌患者细胞免疫功能状况以及白细胞介素-2治疗后机体免疫功能的改变。方法采集患者静脉血,检测患者术前、术后以及白细胞介素-2治疗后CD4、CD8T淋巴细胞水平;对照组为正常献血妇女静脉血。结果宫颈癌患者术前、术后CD4、CD4/CD8值明显低于正常对照组,CD8则明显高于对照组,差异有显著性(P<0.05);经白细胞介素-2治疗后,患者CD4、CD4/CD8显著增高,CD8显著降低,与术前、术后比较差异有显著性(P<0.05)。结论宫颈癌患者细胞免疫功能受到抑制;白细胞介素-2对宫颈癌患者的细胞免疫功能具有调理作用。
Objective To investigate the cellular immune function of cervical cancer patients and the change of immune function after the treatment of interleukin-2. Methods Venous blood was collected from patients and the levels of CD4 and CD8T lymphocytes were measured before and after the operation and the treatment with interleukin-2. The control group was normal blood donation. Results The preoperative and postoperative CD4, CD4 / CD8 values in patients with cervical cancer were significantly lower than those in the normal controls and CD8 was significantly higher than those in the control group (P <0.05). After treatment with interleukin-2, CD4, CD4 / CD8 were significantly increased, CD8 was significantly lower, compared with preoperative and postoperative differences were significant (P <0.05). Conclusion The cellular immune function of patients with cervical cancer is inhibited. Interleukin-2 plays a role in the regulation of cellular immune function in patients with cervical cancer.