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目的：探讨脑出血患者的细胞免疫功能及其临床意义。方法：对４６例脑出血患者及４２例正常对照外周血Ｔ淋巴细胞亚群及血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平进行检测，并对其中 ２１例脑出血患者恢复期外周血Ｔ淋巴细胞亚群及血清ｓＩＬ－２Ｒ水平进行了复查。结果：脑出血组急性期外周血 ＣＤ３数量明显低于对照组，ＣＤ４与对照组比较无显著性差异，ＣＤ８明显高于对照组，ＣＤ４／ＣＤ８比值则显著低于对照组，血清ｓＩＬ－２Ｒ水平显著高于对照组；病情重者、预后差者周围血ＣＤ３数量明显少于病情轻者、预后好者，ＣＤ８数量明显多于病情轻者、预后好者，ＣＤ４／ＣＤ８比值显著低于病情轻者、预后好者，血清ｓＩＬ－２Ｒ水平显著高于病情轻者、预后好者；脑出血组恢复期与急性期比较，周围血ＣＤ３数量明显增多，ＣＤ８明显减少，ＣＤ４／ＣＤ８比值明显升高，血清ｓＩＬ－２Ｒ水平显著降低。结论：脑出血患者细胞免疫功能明显低下。检测外周血Ｔ淋巴细胞亚群分布及血清ｓＩＬ－２Ｒ水平对判断脑出血病情、预后有一定的临床意义。
Objective: To investigate the cellular immune function in patients with intracerebral hemorrhage and its clinical significance. Methods: The levels of peripheral blood T lymphocyte subsets and soluble interleukin-2 receptor (sIL-2R) were detected in 46 patients with cerebral hemorrhage and 42 normal controls, and 21 peripheral blood Blood T lymphocyte subsets and serum sIL-2R levels were reviewed. Results: The number of CD3 in the peripheral blood in acute cerebral hemorrhage group was significantly lower than that in control group. There was no significant difference between CD4 and control group, CD8 was significantly higher than that in control group, CD4 / CD8 ratio was significantly lower than that in control group, serum sIL-2R level Significantly higher than the control group; severe disease, poor prognosis of peripheral blood CD3 was significantly less than mild disease, good prognosis, CD8 was significantly more than the number of mild, good prognosis, CD4 / CD8 ratio was significantly lower than the mild Serum sIL-2R levels were significantly higher than those with mild disease and good prognosis. Compared with the acute phase, the number of CD3, CD8 and CD8 / CD8 in peripheral blood of recovery group were significantly increased , Serum sIL-2R levels were significantly lower. Conclusion: The cellular immune function in patients with intracerebral hemorrhage is obviously low. Detection of peripheral blood T lymphocyte subsets and serum sIL-2R levels in judging the status of cerebral hemorrhage, prognosis of a certain clinical significance.