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目的探讨2型糖尿病患者体内P物质含量与抑郁焦虑症状的关系。方法对2型糖尿病(T2DM)患者80例(包括无并发症及有并发症患者各40例)及健康对照40例分别进行汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)评定;同时测定血浆P物质。结果 T2DM组HAMD、HAMA总分高于健康对照组,并发症组高于无并发症组,差异均有统计学意义(P﹤0.01);伴抑郁、焦虑的T2DM组SP含量显著高于健康对照组(t=4.488、4.632,P﹤0.01);P物质与HAMD、HAMA总分呈显著正相关(r=0.402、0.366,P﹤0.01)。结论 T2DM患者抑郁、焦虑情绪的发生率比较高,尤其是合并有慢性并发症者;抑郁、焦虑组患者血浆P物质浓度升高;抑郁焦虑情绪及慢性并发症分别是独立影响P物质的重要因素。
Objective To investigate the relationship between substance P and depression and anxiety in type 2 diabetic patients. Methods Eighty patients with type 2 diabetes mellitus (T2DM) (including 40 patients without complications and complications) and 40 healthy controls were enrolled in the HAMA, HAMA, ) Assessment; simultaneous determination of plasma substance P. Results The total score of HAMD and HAMA in T2DM group was higher than that in healthy control group, and the complication group was higher than that of non-complication group (P <0.01). The content of SP in T2DM group with depression and anxiety was significantly higher than that in healthy control (T = 4.488, 4.632, P <0.01). There was a significant positive correlation between substance P and total score of HAMD and HAMA (r = 0.402,0.366, P <0.01). Conclusions The incidence of depression and anxiety in T2DM patients is relatively high, especially in patients with chronic complications. In patients with depression and anxiety, the plasma substance P concentration is increased. Depression and anxiety and chronic complications are important factors that independently affect substance P .