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前列环素类似物、内皮素受体拮抗药和磷酸二酯酶抑制药是目前肺动脉高压治疗的最新、最有效的3类药物。西地那非是一个选择性的磷酸二酯酶抑制药,它通过抑制磷酸二酯酶而发挥扩张肺血管作用。临床研究表明西地那非可改善临床症状、提高运动耐量。西地那非具有服用方便、不良反应少等优点。
Prostacyclin analogues, endothelin receptor antagonists and phosphodiesterase inhibitors are the newest and most effective class 3 drugs for the treatment of pulmonary hypertension. Sildenafil is an optional phosphodiesterase inhibitor that exerts the dilated pulmonary vasodilatation by inhibiting phosphodiesterase. Clinical studies have shown that sildenafil can improve clinical symptoms and improve exercise tolerance. Sildenafil has the advantages of easy to take, less adverse reactions.