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OBJECTIVE Pulmonary artery hypertension (PAH) is a severe disease characterized by the mean pulmonary artery pressure exceeding 25 mmHg at rest.PAH could induce right heart failure and has a very high mortality rate.At present, several kinds of drugs have been used in the treatment of PAH.However, most of these drugs aim to relax pulmonary arteries and do not inhibit the injury of vessels.