论文部分内容阅读
目的观察10 mg 或20 mg 阿托伐他汀+长效降压药治疗对颈动脉内膜-中层厚度(IMT)的作用。方法 151例轻度高血压患者随机分为3组,50例用10 mg 阿托伐他汀+氨氯地平+贝那普利治疗,61例用20 mg 阿托伐他汀+氨氯地平+贝那普利治疗,对照组45例采用氨氯地平+贝那普利治疗;观察治疗前、第3、6、9、12个月 IMT、血管舒张功能、低密度脂蛋白胆固醇(LDL-C)等指标变化。结果 10 mg 或20 mg 阿托伐他汀组与对照组比较结果:(1)颈动脉 IMT 减少(P<0.01);(2)血管舒张功能改善(P<0.01);(3)10 mg 阿托伐他汀组 LDL-C 下降30%,20 mg 组 LDL-C下降40.48%(P<0.01)。结论 10或20 mg 阿托伐他汀能够延缓高血压患者的动脉粥样硬化的发展;改善血管内皮功能;达到强化降脂效果。
Objective To observe the effects of 10 mg or 20 mg atorvastatin plus long-acting antihypertensive drugs on carotid intima-media thickness (IMT). Methods One hundred and fifteen patients with mild hypertension were randomly divided into three groups, 50 patients were treated with 10 mg atorvastatin plus amlodipine plus benazepril, and 61 patients were treated with 20 mg atorvastatin plus amlodipine + In the control group, 45 cases were treated with amlodipine and benazepril. IMT, vasodilatation, LDL-C, etc. were observed before treatment and at 3, 6, 9 and 12 months Indicator changes. Results Compared with the control group, the results of 10 mg or 20 mg atorvastatin group showed that: (1) the carotid artery IMT was decreased (P <0.01); (2) the vasodilation was improved (P <0.01); (3) LDL-C decreased by 30% in the statin group and 40.48% (P <0.01) in the 20 mg group. Conclusions Atorvastatin 10 or 20 mg can delay the development of atherosclerosis in hypertensive patients, improve endothelial function and enhance lipid-lowering effect.