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目的:观察经鼻持续气道正压通气(N-CPAP)治疗婴儿重症毛细支气管炎的临床效果。方法:选择0~6个月重症毛细支气管炎患儿118例,随机分为观察组68例和对照组50例。两组均进行常规综合治疗,在此基础上,观察组给予N-CPAP呼吸支持,对照组给予常规方式吸氧。观察并比较两组呼吸频率、心率、经皮血氧饱和度(TcSO2)、血气分析、喘憋缓解时间、住院时间及并发症发生情况。结果:治疗2h后,观察组呼吸频率、心率和TcSO2水平均显著优于对照组(P<0.05);治疗24h后,观察组动脉血氧分压(PaO2)水平显著高于对照组(P<0.05);两组喘憋持续时间比较,观察组非常显著短于对照组(P<0.01);两组住院时间比较,观察组显著短于对照组(P<0.05)。对照组并发呼吸衰竭或心力衰竭5例,观察组未发生严重并发症。结论:应用N-CPAP可改善婴儿重症毛细支气管炎通气换气功能,快速缓解症状,缩短治愈时间。
Objective: To observe the clinical effect of nasal continuous positive airway pressure (N-CPAP) in the treatment of infantile severe bronchiolitis. Methods: A total of 118 children with severe bronchiolitis (0-6 months) were randomly divided into observation group (68 cases) and control group (50 cases). On the basis of this, the observation group was given N-CPAP respiratory support, while the control group was given conventional oxygen therapy. The respiratory rate, heart rate, percutaneous oxygen saturation (TcSO2), blood gas analysis, asthma relief time, hospital stay and complication were observed and compared. Results: After 2 hours of treatment, the respiratory rate, heart rate and TcSO2 level in the observation group were significantly better than those in the control group (P <0.05). After 24 hours of treatment, the PaO2 level in the observation group was significantly higher than that in the control group (P < 0.05). Compared with the control group, the observation group was significantly shorter than the control group (P <0.01). The duration of hospitalization in the two groups was significantly shorter than that in the control group (P <0.05). The control group complicated by respiratory failure or heart failure in 5 cases, the observation group did not occur serious complications. Conclusion: N-CPAP can improve infantile severe bronchiolitis ventilation function, rapid relief of symptoms and shorten the healing time.