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目的:探讨血清中癌相关糖抗原CA199、CA724联合检测在良性胃病与胃癌诊断中的价值。方法:采用电化学发光技术检测40例正常对照组、62例良性胃病、73例胃癌患者血清CA199、CA724的含量。结果:胃癌患者血清CA199、CA724的阳性检测率明显高于良性胃病及正常对照组,差异有显著性(P<0.01),两者联合检测敏感性均显著提高(P<0.05)。结论:血清CA199、CA724联合检测有助于提高胃癌诊断的敏感性。
Objective: To investigate the value of combined detection of CA199 and CA724, a cancer-associated carbohydrate antigen, in the diagnosis of benign gastric diseases and gastric cancer. Methods: The levels of serum CA199 and CA724 in 40 patients with normal gastric cancer, 62 patients with benign gastric disease and 73 patients with gastric cancer were detected by electrochemiluminescence. Results: The positive rates of serum CA199 and CA724 in gastric cancer patients were significantly higher than those in benign gastric diseases and normal controls (P <0.01). The sensitivity of combined detection was significantly increased (P <0.05). Conclusion: The combination of serum CA199 and CA724 can improve the sensitivity of gastric cancer diagnosis.