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目的:探讨老年2型糖尿病患者轻度认知功能障碍（MCI）与体质量指数（BMI）的关系。方法:选取杭州市五云山疗养院2016年1月至2019年5月诊治的2型糖尿病患者327例为2型糖尿病组，其中合并MCI的患者73例为MCI组，未合并MCI的患者254例为非MCI组。选取同期在该院体检的老年健康志愿者100例为对照组。比较各组性别、年龄、受教育年限、家庭月收入、BMI、生活习惯（饮酒、吸烟）及实验室检查指标的差异，使用logistics回归分析判断影响2型糖尿病患者合并MCI的影响因素，使用受试者工作特征（ROC）曲线评估BMI对老年2型糖尿病患者合并MCI的预测价值。结果:2型糖尿病组的年龄、家庭月收入、合并糖尿病家族史比例、BMI、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇（LDL-C）分别为（73.10±9.56）岁、8 926元、189/327例、（24.18±2.64）kg/mn 2、（6.96±0.88）mmol/L、（7.10±0.84）%、（7.32±0.84）mmol/L，均高于对照组的（68.28±8.21）岁、6 715元、13/100例、（22.30±1.74）kg/mn 2、（4.51±0.72）mmol/L、（5.62±0.68）%、（7.04±0.67）mmol/L，差异均有统计学意义（n t=4.554，χn 2=18.601、61.654，n t=6.668，n t=25.360、16.077、3.049，均n P<0.05）。2型糖尿病患者中，MCI组家庭月收入<5 000元的比例、糖尿病家族史、BMI、HbA1c分别为29/73例、60/73例、（24.92±2.43）kg/mn 2、（7.54±0.88）%，非MCI组分别为70/254例、129/254例、（23.77±2.59）kg/mn 2、（6.92±0.81）%，两组差异均有统计学意义（χn 2=6.144、22.927，n t=3.389、5.652，均n P<0.05）。多因素logistics回归分析结果显示：BMI、HbA1c是影响老年2型糖尿病患者合并MCI的影响因素（n OR=0.274、0.192，均n P0.05）。ROC曲线分析显示：当BMI值为24.49 kg/mn 2时，约登指数最大（0.510），对应的灵敏度为83.86%、特异度为67.12%。ROC曲线下面积为0.766［95%CI（0.699~0.832）］。n 结论:BMI是老年2型糖尿病患者MCI发生的影响因素，且可能是早期预测疾病的重要指标之一。“,”Objective:To investigate the relationship between mild cognitive impairment (MCI) and body mass index (BMI) in older adult patients with type 2 diabetes mellitus (T2DM).Methods:A total of 327 patients with T2DM who received treatment in Wuyunshan Sanatorium from January 2016 to May 2019 were included in the T2DM group. Patients in theT2DM group were subdivided into an MCI group (n n = 73) and a non-MCI group (n n = 254) according to whether they had MCI. An additional 100 older adult volunteers who concurrently received physical examination were included in the control group. Sex, age, years of education, monthly family income, body mass index, living habits (drinking, smoking) and laboratory indexes were compared among the groups. The influential factors of MCI in patients with T2DM were analyzed by logistic regression model. The predictive value of BMI for MCI in older adult patients with T2DM was evaluated by receiver operating characteristic (ROC) curve.n Results:Age, monthly family income, the proportion of patients with a history of diabetes mellitus, BMI, fasting blood glucose, glycosylated hemoglobin (HbA1C), low-density lipoprotein cholesterol (LDL-C) in the T2DM group were (73.10 ± 9.56) years old, 8 926 yuan RMB, 189/327, (24.18 ± 2.64) kg/mn 2, (6.96 ± 0.88) mmol/L, (7.10 ± 0.84)%, (7.32 ± 0.84) mmol/L, respectively, which were higher than those in the control group [(68.28 ± 8.21) years old, 6 715 yuan RMB, 13/100, (22.30 ± 1.74) kg/mn 2, (4.51 ± 0.72) mmol/L, (5.62 ± 0.68)%, (7.04 ± 0.67) mmol/L, n t = 4.554, n χ2 = 18.601, 61.654, n t = 6.668, n t = 25.360, 16.077, 3.049, all n P < 0.05]. In the MCI group, the proportion of patients having a monthly family income < 5 000 yuan RMB, the proportion of patients having a history of diabetes mellitus, BMI, HbA1c value were 29/73, 60/73, (24.92 ± 2.43) kg/m n 2, (7.54 ± 0.88)%, respectively , while they were 70/254, 129/254, (23.77 ± 2.59) kg/mn 2, (6.92 ± 0.81)%, respectively in the non-MCI group. There were significant differences in these indexes between MCI and non-MCI groups (n χ2 = 6.144, 22.927, n t = 3.389, 5.652, all n P < 0.05). Multivariate logistic regression analysis showed that BMI and HbA1c were the influential factors of MCI complicated by T2DM in older adult patients ( n OR = 0.274, 0.192, both n P 0.05). The ROC curve revealed that when BMI value was 24.49 kg/m n 2, Youden index was the largest (0.510), the corresponding sensitivity was 83.86%, and the specificity was 67.12%. The area under the ROC curve was 0.766 [95% n CI (0.699 - 0.832)].n Conclusion:BMI is an influential factor of MCI development in older adult patients with T2DM, and may be one of the important indicators for early prediction of MCI.