论文部分内容阅读
目的探讨IgA肾病临床表现与病理的关系。方法对1996—2005上海交通大学附属儿童医院住院的77例患儿,进行肾组织活检确诊为原发性IgA肾病。参照Lee修改的Meadow病理分级标准将IgA肾病分级。结果血尿蛋白尿33例,孤立性血尿22例,肾病综合征12例,急性肾炎9例,孤立性蛋白尿1例。病理分级:Ⅰ级11例,Ⅱ级14例,Ⅲ级47例,Ⅳ级5例。结论呈孤立性血尿的IgA肾病病理改变相对较轻,随着蛋白尿的增多,肾损害逐渐加重。
Objective To investigate the relationship between clinical manifestations and pathology of IgA nephropathy. Methods Totally 77 children admitted to Children’s Hospital of Shanghai Jiao Tong University from 1996 to 2005 were diagnosed as primary IgA nephropathy by biopsy of the kidney. IgA nephropathy was graded according to Lee’s modified Meadow pathological grading criteria. Results 33 cases of hematuria proteinuria, 22 cases of isolated hematuria, 12 cases of nephrotic syndrome, 9 cases of acute nephritis and 1 case of isolated proteinuria. Pathological grade: grade Ⅰ in 11 cases, grade Ⅱ in 14 cases, grade Ⅲ in 47 cases, grade Ⅳ in 5 cases. Conclusion The pathological changes of IgA nephropathy with isolated hematuria are relatively mild. With the increase of proteinuria, the renal damage gradually aggravates.