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目的:研究丹参酮B钠盐对局灶性脑缺血再灌注损伤大鼠海马神经元的保护作用。方法:应用线栓法可逆性的阻塞大鼠大脑中动脉,制备大鼠局灶性脑缺血再灌注损伤模型。复灌24h后对大鼠进行神经学评分,并测定脑梗死率和含水量。制备脑组织病理切片,观察丹参酮B钠盐对局灶性脑缺血再灌注损伤大鼠海马组织病理学影响。结果:丹参酮B钠盐能使缺血再灌注后大鼠的神经行为明显改善,显著降低脑梗死率和含水量。脑组织切片病理学检查表明丹参酮B钠盐对缺血再灌注损伤大鼠海马具有明显保护作用。结论:丹参酮B钠盐对大鼠局灶性脑缺血再灌注损伤大鼠海马神经元具有很好的保护作用。
Objective: To study the protective effect of tanshinone B sodium on hippocampal neurons in rats with focal cerebral ischemia-reperfusion injury. Methods: The rat middle cerebral artery (MCAO) was blocked by reversible occlusion method and the focal cerebral ischemia-reperfusion injury model was established. Neurological scores of rats were recovered 24 hours after reperfusion, and infarction rate and water content were measured. The histopathology of brain tissue was made and the effect of tanshinone B sodium on hippocampal histopathology was observed after focal cerebral ischemia-reperfusion injury in rats. Results: Tanshinone B sodium significantly improved the neurological behavior of rats after ischemia-reperfusion, and significantly reduced cerebral infarction rate and water content. Pathological examination of brain tissue sections showed that sodium tanshinone B had a significant protective effect on hippocampus of ischemia-reperfusion injury rats. CONCLUSION: Tanshinone B sodium has a good protective effect on hippocampal neurons in rats with focal cerebral ischemia-reperfusion injury.