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目的研究ABCG2与Hif-2α在乳头状甲状腺癌患者外周血中的表达与预后相关性。方法选取26例乳头状甲状腺癌患者作为观察组并给予手术治疗,同期健康志愿者26例作为对照组。比较观察组与对照组外周血中ABCG2与Hif-2α mRNA表达情况。结果观察组外周血中ABCG2与Hif-2α mRNA表达水平显著高于对照组(P<0.05);Ⅲ期和Ⅳ期患者ABCG2与Hif-2α mRNA相对水平显著高于其他分期(P<0.05)。术后1~3年,死亡患者术前外周血中ABCG2 mRNA相对水平均显著高于生存患者(P<0.05);术后1~2年,死亡患者术前外周血中Hif-2α mRNA相对水平均显著高于生存患者(P<0.05)。结论 PTC患者外周血中ABCG2与Hif-2α mRNA表达水平与PTC分期存在相关性,并在预后中具有一定临床价值。
Objective To study the correlation between the expression of ABCG2 and Hif-2α in peripheral blood of patients with papillary thyroid carcinoma and their prognosis. Methods Twenty-six patients with papillary thyroid carcinoma were selected as the observation group and received surgical treatment. Twenty-six healthy volunteers were selected as the control group. The expressions of ABCG2 and Hif-2α mRNA in the peripheral blood of the observation group and the control group were compared. Results The expression of ABCG2 and Hif-2α mRNA in the peripheral blood of observation group was significantly higher than that of control group (P <0.05). The relative levels of ABCG2 and Hif-2α mRNA in stage Ⅲ and Ⅳ were significantly higher than those in other stages (P <0.05). The relative levels of ABCG2 mRNA in the peripheral blood of the deceased patients were significantly higher than those of the survivors (P <0.05) 1 to 3 years after surgery. The relative levels of Hif-2α mRNA Were significantly higher than the survival of patients (P <0.05). Conclusion The expression of ABCG2 and Hif-2α mRNA in peripheral blood of patients with PTC is correlated with the stage of PTC and has certain clinical value in prognosis.