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采用流式细胞术和细胞免疫荧光染色技术，对４２例膀胱移行细胞癌细胞Ｐ５３蛋白表达和ＤＮＡ倍体进行定量分析，结果表明，Ｐ５３表达与肿瘤分级密切相关。结合Ｐ５３表达和ＤＮＡ倍体对预后作了综合分析，结果显示，Ｐ５３阳性异倍体肿瘤患者的生存率最低，Ｐ５３阳性肿瘤患者的生存率次之，而二倍体肿瘤患者的生存率最高。在复发的肿瘤中，Ｐ５３阳性表达（８１．３％）显著高于Ｐ５３阴性表达（１８．７％）。提示：测定膀胱肿瘤Ｐ５３表达，对预后可作出客观评价。
Flow cytometry and immunofluorescence staining were used to quantify P53 protein expression and DNA ploidy in 42 cases of BTCC. The results showed that P53 expression was closely related to tumor grade. Combined with P53 expression and DNA ploidy on the prognosis of a comprehensive analysis of the results showed that the P53 positive aneuploid tumor patients with the lowest survival rate, P53 positive tumor survival rate was second, and the highest survival rate of diploid tumor patients. In recurrent tumors, P53 positive expression (81.3%) was significantly higher than P53 negative expression (18.7%). Tip: Determination of bladder tumor P53 expression, the prognosis can make an objective assessment.