采用随机试验研究40名中国健康志愿者单次口服国产格列美脲的耐受性。结果表明:单次口服1～10mg格列美脲,受试者体温、脉搏、血压、心电图、脑电图、血常规、尿常规、血沉、肝功能、肾功能、电解质等各项指标测定值均在正常范围内,仅见少数血糖降低(8例次)、头晕(2例次)等一过性轻微的不良反应。提示:国人对单次口服格列美脲至10mg剂量比较安全,耐受性较好。 A randomized trial of 40 Chinese healthy volunteers orally administered glimepiride alone was tolerated. The results showed that the body temperature, pulse, blood pressure, electrocardiogram, electroencephalogram, blood routine, urine routine, erythrocyte sedimentation rate, liver function, renal function, electrolytes and other indexes measured in a single oral dose of 1 ~ 10mg glimepiride All within the normal range, only a handful of minor adverse reactions such as a slight reduction of blood sugar (8 cases) and dizziness (2 cases). Tip: people on a single oral glimepiride to 10mg dose safer, better tolerated.