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目的:分析多重耐药菌(MDRO)感染的特点,采取相应的干预措施,降低感染率。方法:对湖州市第三人民医院2010年1月-2010年12月的MDRO感染患者为对照组,进行回顾性调查,分析原因,提出干预措施;对2011年1月-2011年12月的MDRO感染患者为干预组,进行前瞻性调查,并采取一系列干预措施。将数据进行统计学处理。结果:对照组耐甲氧西林金黄色葡萄球菌(MRSA)阳性率67.05%,干预组为47.09%;对照组产超广谱β-内酰胺酶(产ESBLS)大肠埃希菌阳性率68.90%,干预组为44.15%;对照组产ESBLS肺炎克雷伯菌阳性率48.20%,干预组为32.77%;对照组耐碳青霉烯类抗菌药物鲍曼不动杆菌(CR-AB)阳性率35.24%,干预组为16.52%;对照组多重耐药/泛耐药铜绿假单胞菌(MDR/PDR-PA)阳性率22.48%,干预组为10.71%。对照组与干预组各类耐药菌阳性率差异有统计学意义(P<0.01)。结论:经实施多项干预措施,MDRO感染率显著降低。
Objective: To analyze the characteristics of multi-drug resistant bacteria (MDRO) infection and take appropriate interventions to reduce the infection rate. Methods: The Third People’s Hospital of Huzhou from January 2010 to December 2010 in patients with MDRO infection as a control group, a retrospective survey to analyze the causes and propose interventions; January 2011-December 2011 MDRO Infected patients were intervention group, prospective investigation, and take a series of interventions. The data were statistically processed. Results: The positive rate of methicillin-resistant Staphylococcus aureus (MRSA) was 67.05% in control group and 47.09% in intervention group. The positive rate of ESBLs producing Escherichia coli in control group was 68.90% The positive rate of ESBLs-producing Klebsiella pneumoniae was 48.20% in the control group and 32.77% in the intervention group. The positive rate of carbapenem-resistant Acinetobacter baumannii (CR-AB) in the control group was 35.24% , 16.52% in the intervention group. The positive rate of MDR / PDR-PA in the control group was 22.48%, which was 10.71% in the intervention group. There was significant difference between the control group and the intervention group (P <0.01). Conclusions: MDRO infection rates were significantly reduced after several interventions were implemented.