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为探讨结直肠癌患者手术前后血清唾液酸（Ｓｉａｌｉｃａｃｉｄ，ＳＡ）浓度的变化及临床意义，作者采用单一试剂比色法检测了４５例正常人和５３例结直肠癌患者的血清ＳＡ浓度。结果显示，结直肠癌组血清ＳＡ浓度显著高于正常对照组（Ｐ＜０．０１），且Ｄｕｋｅｓ′Ｃ组显著高于Ｄｕｋｅｓ′Ｂ组（Ｐ＜０．０５），Ｄｕｋｅｓ′Ｂ组显著高于Ｄｕｋｅｓ′Ａ组（Ｐ＜０．０５），根治性切除术后各组的血清ＳＡ均显著下降（Ｐ＜０．０５）。表明血清ＳＡ浓度可作为结直肠癌辅助诊断和评估疗效的指标之一。
To investigate the changes and clinical significance of serum sialic acid (SA) concentrations in patients with colorectal cancer before and after surgery, the authors used a single reagent colorimetric method to detect serum SA concentrations in 45 normal controls and 53 patients with colorectal cancer. The results showed that the serum SA concentration in the colorectal cancer group was significantly higher than that in the normal control group (P<0.01), and was significantly higher in the Dukes’C group than in the Dukes’B group (P<0.05), and was significantly higher in the Dukes’B group. In the Dukes’A group (P<0.05), serum SA in all groups decreased significantly after radical resection (P<0.05). It has been shown that serum SA concentration can be used as an indicator for the diagnosis and evaluation of efficacy of colorectal cancer.