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ACM(Adacinomycin如图1示)是蒽环类抗菌素,对许多肿瘤有抗癌活性,并且比其衍生物,临床广泛使用的阿霉素(Aclriamycin,ADM,如图1示)心脏毒性低。人们已用电子吸收光谱、荧光和~(31)P核磁共振以及共振拉曼(共振增强ACM蒽环色团的拉曼谱)研究了ACM与DNA相互作用,结果表明ACM色团插入DNA的T-A位置。至今尚未用紫外共振拉曼光谱(UVRRS)研究过ACM与DNA相互作用特性。本文用274nm紫外激光共振增强DNA碱基的拉曼光谱(而不受ACM拉曼光谱的干扰),从DNA拉曼光谱在与ACM作用前后的变化分析得出相互作用特性。
ACM (Adacinomycin shown in Figure 1) is an anthracycline antibacterial, anticancer activity on many tumors, and its cardiotoxicity than its derivatives, clinically widely used doxorubicin (ADM, shown in Figure 1). The interaction of ACM with DNA has been studied by electron absorption spectroscopy, fluorescence and ~ (31) P nuclear magnetic resonance and resonance Raman (resonance enhanced Raman spectra of ACM anthracene chromophores). The results show that the ACM chromophore is inserted into the TA position. Up to now, the interaction between ACM and DNA has not been studied by ultraviolet resonance Raman spectroscopy (UVRRS). In this paper, Raman spectra of DNA bases were enhanced by 274nm UV laser resonance (without interference from ACM Raman spectra), and the interaction characteristics of DNA Raman spectra were analyzed before and after the interaction with ACM.