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利福平所致急性肾衰多见于间歇性或单一的短期疗程。但是,也可发生在连续用药时。作者报告一例连续使用利福平期间发生急性肾衰的病人,遗留的肾损害持续达12个月。病人男性,45岁,因活动性肺结核入院治疗。涂片查抗酸杆菌阳性,血尿素氮10mg/100ml;血肌酐0.7mg/100ml。肝功能异常,表现为:白蛋白1.6g/100ml;血胆红素2.2mg/100ml(直接2.0mg/100ml);血清谷草转氨酶87u(正常<40u);乳酸脱氢酶275u/100ml(正常<250u/100ml);碱性磷酸酶340u(正
Rifampicin induced acute renal failure more common in intermittent or single short-term course of treatment. However, it can also occur at the time of continuous administration. The authors report a patient who had acute renal failure during the continuous use of rifampicin, with persistent kidney damage lasting up to 12 months. Male patient, 45 years old, admitted to hospital for active tuberculosis. Smear acid-fast bacilli positive, blood urea nitrogen 10mg / 100ml; serum creatinine 0.7mg / 100ml. Liver dysfunction, manifested as: albumin 1.6g / 100ml; bilirubin 2.2mg / 100ml (direct 2.0mg / 100ml); serum aspartate aminotransferase 87u (normal <40u); lactate dehydrogenase 275u / 100ml (normal < 250u / 100ml); alkaline phosphatase 340u (positive