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[目的]观察黄芪枳实汤联合化疗治疗乳腺癌疗效。[方法]使用随机平行对照方法,将68例住院患者按随机数字表方法简单随机分为两组。对照组34例TE方案,紫杉醇175mg/m2+5%葡萄糖500m L,静滴3h,1次/d;表阿霉素60mg/m2+5%葡萄糖40m L,静推,1次/d,每21d重复1次。治疗组34例黄芪枳实汤:当归、黄芪、党参、首乌、山药各、甘草、黄精、大黄、鸡内金、元参、白芍、枳实各30g,山楂、沙参各35g,山慈菇、穿山藤、半枝莲、半边莲各10g,七叶莲、还魂草、七星剑各15g,蛇芋10g,水煎300m L,3次/d,口服;化疗治疗同对照组。连续治疗21d为1疗程。观测临床症状、白介素-2(IL-2)、白介素-6(IL-6)、γ-干扰素(IFN-γ)、白介素-4(IL-4)、生活质量评分(KPS)、不良反应。连续治疗3疗程(210d),判定疗效。[结果]治疗组CR0例,PR16例,NC13例,PD5例,总有效率85.29%;对照组CR0例,PR7例,NC17例,PD10例,总有效率70.59%;两组间无明显差异(P>0.05)。IL-2,IL-4,IL-6,IFN-γ两组均有改善(P<0.01,P<0.05),治疗组改善优于对照组(P<0.05,P<0.01)。KPS评分升高、稳定人数两组间无明显差异(P>0.05),下降人数治疗组优于对照组(P<0.05)。[结论]黄芪枳实汤联合化疗治疗乳腺癌,可显著改体淋巴因子水平,提高免疫,值得深入研究。
[Objective] To observe the curative effect of Astragalus and Zhishi decoction combined with chemotherapy on breast cancer. [Methods] Using randomized parallel control method, 68 inpatients were randomly divided into two groups according to random number table method. Control group of 34 cases of TE program, paclitaxel 175mg / m2 +5% glucose 500m L, intravenous infusion 3h, 1 / d; epirubicin 60mg / m2 +5% glucose 40m L, 21d repeated 1 time. The treatment group of 34 cases of Astragalus Fructus Aurantii soup: Angelica, Astragalus, Codonopsis, Radix, yam, licorice, Polygonatum, rhubarb, chickens gold, ginseng, white peony root, citrus aurantium each 30g, hawthorn, Radix 35g, Arrowheadia 10g, decoction 300m L, 3 times / d, oral; chemotherapy treatment with the control group. Continuous treatment of 21d for a course of treatment. The clinical symptoms, the levels of IL-2, IL-6, IFN-γ, IL-4, KPS, adverse reactions . Continuous treatment of three courses (210d), to determine the efficacy. [Results] CR0, PR16, NC13 and PD5 in the treatment group, the total effective rate was 85.29%; CR0, PR7, NC17 and PD10 in the control group, the total effective rate was 70.59%; there was no significant difference between the two groups P> 0.05). IL-2, IL-4, IL-6 and IFN-γ in both groups were improved (P <0.01, P <0.05), and improvement in treatment group was better than that in control group (P <0.05, P <0.01). There was no significant difference between the two groups (P> 0.05). The number of decline in the treatment group was better than that in the control group (P <0.05). [Conclusion] Astragalus and Zhishi decoction combined with chemotherapy for breast cancer can significantly change the level of lymphokines and improve immunity, which deserves further study.