目的探讨糖尿病周围神经病变(DPN)患者神经传导速度(NCV)、F波及交感神经皮肤反应(SSR)的变化特点及临床应用价值。方法 97例DPN患者进行神经电生理检查,包括运动神经传导速度(MCV)、感觉神经传导速度(SCV)、F波及SSR检测。结果异常率分别为SSR 75.2%,NCV 48.8%,F波34.5%,下肢神经病变重于上肢(P<0.05)。结论 NCV、F波及SSR联合应用可全面地评估糖尿病周围神经的损害,三者相辅相成,缺一不可。 Objective To investigate the changes of nerve conduction velocity (NCV), F-wave and sympathetic skin reaction (SSR) in patients with diabetic peripheral neuropathy (DPN) and its clinical value. Methods Ninety-seven DPN patients underwent electrophysiological examination including motor nerve conduction velocity (MCV), sensory nerve conduction velocity (SCV), F-wave and SSR. Results The rates of abnormalities were 75.2% for SSR, 48.8% for NCV and 34.5% for F, respectively. The severity of lower limb neuropathy was higher than that of upper limbs (P <0.05). Conclusion Combined application of NCV, F-wave and SSR can comprehensively evaluate the damage of peripheral nerves in diabetes. The three are mutually reinforcing and indispensable.