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基底膜是维系上皮与上皮下结缔组织间正常生理活动的一个重要结构。基底膜完整性的破坏常与肿瘤发生、浸润及转移有关。高分化且具有良好肿瘤-基质界面的癌瘤通常具有完整的基底膜。基底膜区结构蛋白主要有层粘连蛋白、Ⅳ型胶原、Ⅶ型胶原和半桥粒蛋白等。本文综述了其在口腔癌及癌前病变方面的研究概况。
Basement membrane is to maintain epithelial and subepithelial connective tissue of the normal physiological activity of an important structure. The destruction of basement membrane integrity often associated with tumorigenesis, invasion and metastasis. A well-differentiated carcinoma with a good tumor-matrix interface usually has a complete basement membrane. Basement membrane structure proteins are laminin, collagen type IV, collagen type VII and hemidesmosomes. This article summarizes its research status in oral cancer and precancerous lesions.