论文部分内容阅读
目的 探讨慢性肾功能衰竭患者血液透析前后的血浆丙二醛 (MDA)和超氧化物歧化酶 (SOD)含量变化的临床意义。方法 用硫代巴比妥法和黄嘌呤氧化酶法测定慢性肾功能衰竭患者血液透析前、后MDA和SOD含量变化。结果 慢性肾功能衰竭患者血液透析后血浆中MDA较血液透析前明显降低 ,而SOD活性则显著升高。结论 血液透析疗法可以减轻自由基对慢性肾功能衰竭患者组织、器官的损伤 ,也预示着应用抗氧化剂可能成为有益的治疗措施之一。
Objective To investigate the clinical significance of plasma malondialdehyde (MDA) and superoxide dismutase (SOD) levels in patients with chronic renal failure before and after hemodialysis. Methods The contents of MDA and SOD in patients with chronic renal failure before and after hemodialysis were measured by thiobarbiturine and xanthine oxidase method. Results The level of plasma MDA in hemodialysis patients after chronic hemodialysis was significantly lower than that before hemodialysis, while the activity of SOD was significantly increased. Conclusion Hemodialysis can reduce the damage of free radicals to tissues and organs in patients with chronic renal failure, and also indicate that the use of antioxidants may be one of the beneficial treatment measures.