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预测小细胞肺癌(SCLC)生存率最重要的因素是有否远处转移灶。也有人认为转移灶的数目是决定广泛期SCLC 患者预后的强有力指标。SCLC 常规的分期需要一系列显象技术,包括头颅和腹部CT、骨扫描、骨髓检查,费用昂贵且费时。采用放射免疫显象,可发现常规检查方法不易检出的病灶,并可获得特异性组织相关抗原的资料。作者用~(99m)Tc 标记的单克隆抗体(单抗)NR-LU-10 F_(ab)显象检测SCLC,并比较放射免疫显象和常规诊断方法对SCLC 分期的价值。患者和方法17例经病理学证实为SCLC 的患
The most important factor predicting the survival rate of small cell lung cancer (SCLC) is whether there is a distant metastasis. It has also been suggested that the number of metastases is a powerful indicator of the prognosis of patients with extensive SCLC. The conventional staging of SCLC requires a series of imaging techniques, including CT of head and abdomen, bone scan, and bone marrow examination, which are expensive and time consuming. Using radioimmunoimaging, lesions that are not easily detectable by routine examination methods can be found and specific tissue-associated antigen data can be obtained. The authors used a ~(99m)Tc-labeled monoclonal antibody (mAb) NR-LU-10 F_(ab) scintigraphy to detect SCLC and compared the value of radioimmunoimaging and conventional diagnostic methods for SCLC staging. Patients and Methods 17 patients with pathologically confirmed SCLC