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目的研究大蒜皮中的肉桂酰胺类化合物N-trans-feruloyloctopamine(FO)对老年痴呆模型大鼠的治疗作用。方法采用Meynert基底核注射Aβ1-40建立老年痴呆大鼠模型,再给予FO进行灌胃后,测定大鼠脑内乙酰胆碱(Ach)、乙酰胆碱转移酶(Ch AT)及乙酰胆碱酯酶(Ach E)活性等指标,HE染色后观察大鼠海马区神经细胞形态变化。结果与模型组比较,酪氨酸酶抑制剂FO组的Ach,Ch AT和Ach E均具有显著性差异(P<0.05,P<0.01);病理结果显示FO对Aβ引起的大鼠海马皮层神经元变性坏死症状明显改善。结论 FO对大鼠AD模型具有较好防治作用。
Objective To study the therapeutic effect of cinnamate N-trans-feruloyloctopamine (FO) in garlic cloves on Alzheimer’s disease model rats. Methods A rat model of Alzheimer ’s disease (AD) was established by injection of Aβ1-40 in the basilar nucleus of Meynert. After intragastric administration of FO, the activity of acetylcholine (Ach), acetylcholinesterase (ChAT) and acetylcholinesterase (AchE) The morphological changes of neurons in hippocampus of rats were observed by HE staining. Results Compared with the model group, Ach, Ch AT and Ach E in the tyrosinase inhibitor FO group were significantly different (P <0.05, P <0.01). The pathological results showed that FO had a significant effect on the Aβ-induced hippocampal cortical neurons Metamorphosis and necrosis improved significantly. Conclusion FO has good preventive and therapeutic effects on AD model in rats.