侵袭性垂体腺瘤因其侵袭性生长,手术全切率低,复发率高,治疗非常困难。其诊断缺乏特异性的分子生物学标准,主要依靠影像学,术中所见和术后病检。近年来随着神经内镜、术中MRI、γ刀的应用及药物治疗和放射治疗水平的提高,侵袭性垂体腺瘤的治疗效果明显改善。但任何一种单一的治疗都很难治愈侵袭性垂体腺瘤,还需要多学科干预的综合治疗和密切的随访。 Invasive pituitary adenomas due to its aggressive growth, low surgical resection rate, high recurrence rate, the treatment is very difficult. The diagnosis of the lack of specific molecular biology standards, mainly rely on imaging, intraoperative findings and postoperative pathological examination. In recent years, with the neuroendoscopy, intraoperative MRI, gamma knife application and drug treatment and radiation therapy levels, the treatment of invasive pituitary adenomas significantly improved. However, any one single treatment is difficult to cure invasive pituitary adenomas, but also requires comprehensive treatment of multidisciplinary interventions and close follow-up.