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目的 探讨血清CA12 5值对子宫内膜癌早期诊断、监测病情变化和预测预后的价值。方法 用免疫化学法检测 5 5例子宫内膜癌患者和 16例良性子宫病变患者血清CA12 5水平。结果 良性子宫病变和 4 4例手术分期为Ⅰ期的子宫内膜癌患者血清CA12 5阳性率分别为 19 4 %和 2 7 3% ,两者相比 ,P >0 0 5 ,无显著性差异 (P>0 0 5 )。手术分期为Ⅰ期和 10例晚期病人 (Ⅲ期 +Ⅳ期 )血清CA12 5的阳性率各为 2 7 3%和 70 % ,两者相比 ,有显著性差异 (P <0 0 5 )。 30例Ⅰa期 +Ⅰb期和 14例Ⅰc期病人血清CA12 5的阳性率分别为 2 0 %和 4 7 8% ,两者相比 ,无显著性差异 (P >0 0 5 )。病理分级中 30例G1、2 0例G2 、5例G3 血清CA12 5的阳性率分别为 2 0 %、4 5 %、80 % ,三者相比 ,相互之间有显著性差异 (P <0 0 5 )。结论 血清CA12 5的检测对早期诊断子宫内膜癌缺乏敏感性 ,对早期内膜癌患者预测手术分期 ,Ⅰc期无明显的参考价值 ,但与手术分期和病理分级密切相关 ,可能对预测预后提供一定的参考价值
Objective To investigate the value of serum CA12 5 in the early diagnosis of endometrial cancer, monitor the change of disease and prognosis. Methods Serum levels of CA12 5 in 55 patients with endometrial carcinoma and 16 patients with benign uterine lesions were detected by immunochemistry. Results The positive rates of serum CA12 5 in benign uterine lesions and 44 cases of stage Ⅰ endometrial cancer were 19 4% and 27 3% respectively, there was no significant difference between the two groups (P> 0.05) (P> 0 0 5). The positive rates of serum CA12 5 in surgical stage Ⅰ and in 10 late stage patients (stage Ⅲ + Ⅳ) were respectively 27.3% and 70%, which were significantly different (P <0.05). The positive rates of serum CA12 5 in 30 cases of stage Ⅰa + Ⅰb and 14 cases of stage Ⅰc were 20% and 47% respectively, there was no significant difference between the two groups (P> 0.05). The positive rates of 30 cases of G1, 20 cases of G2 and 5 cases of G3 serum CA12 5 were 20%, 45%, 80% respectively, there was a significant difference between them (P <0 0 5). Conclusion The detection of serum CA12 5 is not sensitive to the early diagnosis of endometrial cancer. It is of great value to predict the stage of surgery and stage Ⅰc in patients with early endometrial cancer, but it is closely related to the surgical stage and pathological grade, which may provide prognostic prognosis Certain reference value