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患者女性,24岁,已婚。因停经、乳房变小、多毛、阴蒂增大、声音增粗8月余入院。住院体检:体温正常,脉搏76次/分,血压120/70mmHg。发育正常。皮肤粗糙,头发粗黑,眉浓,唇周有须,喉结不增大,发音低沉。四肢粗壮多毳毛,心脏可闻多发性早搏,未见扩大及其他病变。两肺阴性。肝、脾肋下未触及。腹部平软,未及肿块,会阴部阴毛呈棱形分布,阴蒂明显增大,长约3 cm,直径约0.3cm。妇产科检查:子宫及双侧附件正常。实验室检查:24小时尿测定17—酮类固醇20mg,17—羟类固醇13.1mg;AcTH刺激试验测定17—酮类固醇比基础值上升10mg(≥50%)、17—羟类固醇轻度上升(<
Female patient, 24 years old, married. Due to menopause, smaller breasts, hairy, clitoral enlargement, sound thickening more than eight months admitted to the hospital. Inpatient examination: normal body temperature, pulse 76 beats/minute, blood pressure 120/70 mmHg. Normal development. The skin is rough, the hair is thick black, the eyebrows are thick, the lips have to be thick, the throat is not enlarged, and the pronunciation is low. The limbs are thick and plucked, and the heart can hear multiple premature beats. No enlargement and other lesions are seen. Two lungs are negative. The liver and spleen did not touch the ribs. The abdomen was soft, with no mass, and the perineal pubic hair had a prismatic distribution. The clitoris was significantly enlarged, about 3 cm in length and 0.3 cm in diameter. Obstetrics and Gynecology examination: normal uterus and bilateral attachments. Laboratory tests: 24-hour urine assay 17 - ketone steroids 20mg, 17-hydroxysteroids 13.1mg; AcTH stimulation test measured 17-ketosteroids increased 10mg (≥ 50%) from the baseline value, 17-hydroxysteroids increased slightly (<