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目的对常用抗菌药物的给药时间以及临床合理用药情况进行探讨分析。方法选取我院2016年7月至2017年6月使用抗菌药物进行临床治疗的94例患者,采用双盲实验法将患者均分为两个分析组,根据抗菌药物的效果药效参数,为47例分析A组患者进行给药方案设计及给药时间控制,而对47例分析B组患者则不实施给药时间控制,分析两组的给药合理性以及不良用药反应的发生率。结果分析A组患者按照临床设计的给药方案及进行给药时间控制处理后,使抗菌药物治疗的效果大大提升,其给药合理性高达91.49%(43/47);而分析B组患者的给药合理性为70.21%(33/47),两组结果间的差异有统计学意义(P<0.05);而且分析A组不良用药反应的发生率仅为8.51%(4/47),分析B组的为29.79%(14/47),统计学意义可显著表达(P<0.05)。结论在为患者使用抗菌药物治疗时,应针对其不同类型设计合理的给药时间方案,并进行用药间隔控制处理,有助于提升常给药合理性、降低不良用药反应的发生率、确保临床用药安全合理,具有重大的临床意义及现实意义。
Objective To investigate the time of administration of commonly used antibacterial drugs and clinical rational use of drugs. Methods Ninety-four patients who were treated with antimicrobial agents in our hospital from July 2016 to June 2017 were divided into two groups according to the double-blind method. According to the efficacy parameters of antibacterials, A group of patients were analyzed for the design of drug delivery schedule and administration time, while 47 patients in group B were not administered the time control, the rationality of the two groups and the incidence of adverse drug reactions were analyzed. Results Analysis A group of patients in accordance with the clinical design of the dosing schedule and time to control the treatment, so that the effect of antimicrobial agents greatly improved, its administration as high as 91.49% (43/47); and analysis of patients in group B The rationality of drug administration was 70.21% (33/47), the difference between the two groups was statistically significant (P <0.05). The incidence of adverse drug reactions in group A was only 8.51% (4/47) In group B, 29.79% (14/47) were statistically significant (P <0.05). Conclusions When using antimicrobial drugs for patients, we should design a reasonable dosage schedule for different types of patients and conduct interval control treatment to improve the rationality of regular administration, reduce the incidence of adverse drug reactions, and ensure that clinical Drug safety and reasonable, with great clinical significance and practical significance.