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目的分析联合应用氟西汀与莫沙必利治疗功能性消化不良的临床效果。方法将2012年11月-2013年6月我院143例功能性消化不良患者随机分为观察组(氟西汀与莫沙必利联合用药组)72例及观察组(莫沙必利单用组)71例，比较两组效果。结果观察组显效率明显高于对照组，不良反应发生率与对照组无统计学差异。结论氟西汀应用到功能性消化不良能明显提高疗效，同时不良反应发生率未明显增加。“,”Objective To analyse the clinical effect of mosapride combined with fluoxetine for the treatment of functional dyspepsia and provide some help for clinical treatment. Methods From November 2012 to June 2013, we selected 143 patients with functional dyspepsia as the objects in our hospital. They were randomly divided into observation group(mosapride combined with fluoxetine group, n=72) and control group(simplex mosapride group, n=71). We made a comparison on the clinical effect of two methods. Results In observation group, the efficiency was markedly higher than the control group, the adverse reactions rate was not significant when compared with the control group. Conclusion The fluoxetine for the treatment of functional dyspepsia can significantly improve treatment effect. The incidence of side effects was not elevated markedly.