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目的研究Runx3与fascin在胃癌中的表达,以及二者与胃癌临床病理之间的关系,探讨它们与胃癌临床预后关系。方法采用免疫组织化学方法对150例胃癌的石蜡标本进行Runx3与fascin蛋白表达的检测,观察不同蛋白的表达对患者预后的情况。结果 Runx3在胃癌组织中阴性表达48例,阳性表达102例,阴性表达与TNM分期有关(P<0.05);fascin在胃癌组织中阴性表达90例,阳性表达60例,阳性表达与TNM分期有关(P<0.05);相同TNM分期,不同Runx3、fascin蛋白表达的患者5年生存率有明显差异(P<0.05)。结论 Runx3及fascin蛋白在胃癌中的异常表达与TNM分期有关,相同TNM分期的胃癌患者组织中Runx3和fascin的异常表达对生存率有影响;术后检测Runx3和fascin有助于预后的判定。
Objective To study the expression of Runx3 and fascin in gastric cancer and the relationship between Runx3 and fascin in gastric cancer and the clinical prognosis of gastric cancer. Methods Immunohistochemistry was used to detect the expressions of Runx3 and Fascin in paraffin-embedded specimens of 150 cases of gastric cancer and to observe the prognosis of patients with different protein expression. Results The negative expression of Runx3 in gastric cancer tissues was 48 cases, the positive expression was 102 cases, the negative expression was related to TNM staging (P <0.05). The negative expression of fascin in gastric carcinoma tissues was 90 cases, the positive expression was 60 cases. The positive expression was related to TNM staging P <0.05). In the same TNM stage, the 5-year survival rates of patients with different Runx3 and Fascin protein expressions were significantly different (P <0.05). Conclusion The abnormal expression of Runx3 and fascin in gastric cancer is related to the TNM staging. The abnormal expression of Runx3 and fascin in the same TNM staging affects the survival rate. The detection of Runx3 and fascin helps to determine the prognosis.