目前移植肾近期存活率已明显提高但远期效果却未能相应提高。这主要是因为不少患者在肾移植数月后,移植肾功能进行性减退,最终导致移植肾功能衰竭。通常,移植肾功能丧失与肾小管萎缩和间质纤维化的发展有关。目前移植肾纤维化的主要治疗措施都是非特异的,并且集中在减少有害因 The recent survival rate of renal allografts has been significantly improved but the long-term effects failed to increase accordingly. This is mainly because many patients after renal transplantation months, progressive decline in renal function, eventually leading to renal transplant failure. Often, loss of graft function is associated with the development of tubular atrophy and interstitial fibrosis. At present, the main treatment of renal allograft fibrosis is non-specific, and focused on reducing the harmful effects