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目的回顾性总结132例小细胞肺癌中西医结合治疗结果。方法132例均分型口服中药,中医治则主要是祛痰化瘀、祛风通络、散结润肺,同时口服本院院内制剂肺瘤平膏,15 g/次,3次/d。中药治疗同时全部病人接受化疗,方案以COA、COME、EP、CAP为主,一般2~3周期后与其他方案交替使用。其中53例配合局部放疗,放射总量:40~70 GY。结果随访至2004年12月30日,存活19例,失访20例,死亡93例。生存期自治疗首日至死亡日或失访日止。全组平均、中位生存期分别为20.6月、11月,1、2、3、5年生存率分别为46.97%、18.94%、11.36%和5.30%;中药加放化疗组平均、中位生存期分别为34.9月、16月,1、2、3、5年生存率分别为67.92%、32.07%、22.64%和9.43%;中药加化疗组平均、中位生存期分别为11.6月、8月,1、2、3、5年生存期32.91%、10.13%、3.79%和2.53%。中药加放化疗组和中药加化疗组2、3年生存率相比有极显著性差异,5年生存率有显著性差异。中药加化疗组、中药加放化疗组的5年生存率和中位生存期均高于文献报道。结论中药结合放化疗治疗小细胞肺癌疗效肯定,值得进一步加强研究。
Objective To retrospectively summarize the results of 132 cases of small cell lung cancer treated with integrated traditional Chinese and western medicine. Methods One hundred and thirty-two patients were randomly divided into oral administration of traditional Chinese medicine (TCM). The main traditional Chinese medicine was cured phlegm and blood stasis, Qufeng Tongluo, Sanjie Runfei, oral administration of our hospital product Lung tumor ointment, 15 g / times, 3 times / d. Chinese medicine treatment while all patients undergoing chemotherapy, the program to COA, COME, EP, CAP-based, usually 2 to 3 cycles after alternating with other programs. Of which 53 cases with local radiotherapy, total radiation: 40 ~ 70 GY. Results Follow-up to Dec. 30, 2004, 19 patients survived, 20 patients lost to follow-up, and 93 patients died. Survival period from the first day of treatment to the date of death or lost day. The mean survival time of the whole group was 20.6 months, and the survival rates in 1, 2, 3 and 5 years were 46.97%, 18.94%, 11.36% and 5.30% respectively; mean and median survival The mean survival time of Chinese medicine plus chemotherapy group were 11.6 months and August respectively , 1, 2, 3, 5-year survival of 32.91%, 10.13%, 3.79% and 2.53%. Chinese medicine plus chemotherapy group and traditional Chinese medicine plus chemotherapy group 2, 3-year survival rate compared to a very significant difference, 5-year survival rate was significantly different. The 5-year survival rate and median survival time of traditional Chinese medicine plus chemotherapy group, traditional Chinese medicine plus radiotherapy and chemotherapy group were higher than those reported in the literature. Conclusion Chinese medicine combined with chemoradiotherapy for the treatment of small cell lung cancer is positive, it is worth further study.