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目的我国女性乳腺癌发病率逐年上升,夜间睡眠时间长短可能与一系列健康效应相关,为探究夜间睡眠时间与乳腺癌发病关联性,本研究以唐山开滦集团前瞻性动态队列中的女性人群为基础进行了相关分析。方法采用2006-2011年开滦集团体检人群中女性人群资料,收集社会人口学资料、睡眠习惯、身高、体质量等基线信息及乳腺癌发病结局信息。采用Cox比例风险回归模型分析夜间睡眠时间与女性乳腺癌发病风险的关联性。结果共纳入24 692名女性体检者,总随访108 029.22人年,平均随访时间为4.38年,新发乳腺癌病例107例。以夜间睡眠7h为参比组,单因素分析提示夜间睡眠偏短(≤6h,HR=0.99,95%CI=0.52~1.87)或偏长(≥8h,HR=0.84,95%CI=0.49~1.45)与乳腺癌发病风险无统计学关联。调整年龄、受教育程度、饮酒等混杂因素后,分析仍显示夜间睡眠时间偏短(HR=0.82,95%CI=0.43~1.56)或偏长(HR=0.94,95%CI=0.54~1.64)与女性乳腺癌的发病无统计学关联。按年龄、打鼾情况和BMI分层分析及敏感性分析后,结果仍未发现存在显著性关联。结论本研究结果尚不支持夜间睡眠时间偏短或偏长与女性乳腺癌的发病风险存在关联性。
Objective The incidence of breast cancer in our country is increasing year by year, and the length of nighttime sleep may be related to a series of health effects. In order to explore the correlation between nighttime sleep time and the incidence of breast cancer, this study took the female population of prospective dynamic cohort of Tangshan Kailuan Group as Based on the correlation analysis. Methods The data of female population in the Kailuan Group medical examination population from 2006 to 2011 were collected. Baseline information such as socio-demographic data, sleep habits, height, body weight and breast cancer incidence information were collected. Cox proportional hazards regression model was used to analyze the association between nocturnal sleep time and the risk of developing breast cancer in women. Results A total of 24 692 female subjects were enrolled. The total follow-up was 108,029.22 person-years. The average follow-up time was 4.38 years. 107 cases were newly diagnosed breast cancer. At nighttime sleep for 7h as a reference group, univariate analysis showed that nighttime sleep was short (≤6h, HR = 0.99, 95% CI = 0.52 ~ 1.87) or partial length (≥8h, HR = 0.84, 95% CI = 1.45) and breast cancer risk no statistical correlation. After adjusting for age, education level, drinking and other confounding factors, the analysis showed that nighttime sleep time was short (HR = 0.82, 95% CI = 0.43-1.56) or longer (HR = 0.94, 95% CI = 0.54-1.64) There was no statistical correlation with the incidence of breast cancer in women. By age, snoring and BMI stratification analysis and sensitivity analysis, the results still did not find any significant correlation. Conclusions The results of this study do not support the association of short nighttime sleepiness or partial length with the risk of developing breast cancer in women.