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目的探讨结节性甲状腺肿与食盐加碘后人群尿碘水平的关系。方法采用多阶段分层整群随机抽样方法,以乡镇为单位,将全县分为城镇、山区、平原、沿海、海岛5层;每层随机抽取1个乡镇,每个乡镇随机抽取2个行政村,每个行政村随机抽取100户居民进行调查。结果人群甲状腺结节总异常率为43.66%;山区、平原、沿海、城镇和对照人群甲状腺结节异常率分别为34.07%、45.29%、44.01%、52.86%和42.83%,差异有统计学意义(χ2=19.28,P=0.0007);食用碘盐人群甲状腺结节检出率42.87%与食用非碘盐人群44.32%比较,两者差异无统计学意义(χ2=0.502,P=0.4788);碘缺乏组、碘适宜组、碘足量组和碘过量组4组人群甲状腺结节异常率分别为45.07%、42.72%、41.83%和45.79%,差异无统计学意义(χ2=2.046,P=0.5628);甲状腺B超正常人群尿碘中位数164.50μg/L高于异常人群尿碘中位数115.30μg/L(Z=15.64,P=0.009)。结论没有依据证实结节性甲状腺肿与尿碘水平呈相关关系。
Objective To investigate the relationship between nodular goiter and urinary iodine levels in people after salt iodization. Methods A multistage stratified cluster random sampling method was used to divide the county into five layers of towns, mountains, plains, coastal areas and islands with the township as a unit. One township was randomly selected from each level, and two administrative The village, each administrative village randomly selected 100 households to investigate. Results The total abnormal rate of thyroid nodules in the population was 43.66%. The abnormal rates of thyroid nodules were 34.07%, 45.29%, 44.01%, 52.86% and 42.83% in mountain, plain, coastal, urban and control groups respectively, with statistical significance ( χ2 = 19.28, P = 0.0007). The detection rate of thyroid nodules was 42.87% in the iodized salt group and 44.32% in the non-iodized salt group, there was no significant difference between the two groups (χ2 = 0.502, P = 0.4788) The abnormal rates of thyroid nodules were 45.07%, 42.72%, 41.83% and 45.79% respectively in the four groups (χ2 = 2.046, P = 0.5628), the iodine adequate group, iodine adequate group and iodine excess group The median urinary iodine in patients with thyroid B-normal population was 164.50μg / L higher than that in abnormal population with 115.30μg / L (Z = 15.64, P = 0.009). Conclusion There is no evidence that nodular goiter correlated with urinary iodine level.