基质金属蛋白酶-9(m atrix m etalloproteinase-9,M M P-9)是一种依赖锌离子的蛋白酶,因其表达细胞众多,作用底物广泛而备受重视,与脑血管病发病过程关系密切,已成为研究热点之一。脑缺血后表达的M M P-9能降解基底膜而破坏血脑屏障(blood brain barrier,BBB),导致血管源性脑水 Matrix metalloproteinase-9 (MMP-9) is a zinc ion-dependent protease. Its expression of many cells, the role of a wide range of substrates and much attention, and the pathogenesis of cerebrovascular disease are closely linked , Has become one of the research hot spots. M M P-9 expressed after cerebral ischemia can degrade the basement membrane and destroy the blood-brain barrier (BBB), resulting in vasogenic brain-derived brain water