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研究了黄腐酸(FA)作为一种的新的络合剂,与羟丙基-β-环糊精络合物(Hp-β-CD)相比,对阿司匹林(ASA)分解的影响。ASA与FA以1:0.5、1:1、1:2(物质的量比)络合,并用冷冻干燥、溶剂蒸发和喷雾干燥三种方法进行干燥。ASA-羟丙基-β-环糊精(1:1)络合物通过喷雾干燥制备,并与最佳FA络合物进行比较。将所有的络合物和ASA放入贴好标签的铝塑小包中密封,在温度为40±2℃、相对湿度为75%±5%的稳定暗箱中存放120d。分别在0、30d、60d、90d和120d分析各样品的水杨酸含量。以物质的量比为1:1进行络合的ASA-FA喷雾干燥络合物中水杨酸含量为4.31%,该络合物在所有不同制备方法的络合物中具有最佳稳定性。然而,1:1的ASA-羟丙基-β-环糊精喷雾干燥络合物中测得水杨酸含量只有2.35%。与FA相比,ASA与羟丙基-β-环糊精络合,其稳定性更强。为提高阿司匹林的稳定性,对一种新型FA络合剂进行了研究。与1:1ASA-FA喷雾干燥络合物相比,ASA与羟丙基-β-环糊精1:1络合时,ASA的稳定性有显著改善。
The effect of fulvic acid (FA) as a new complexing agent on the breakdown of aspirin (ASA) compared to hydroxypropyl-β-cyclodextrin complex (Hp-β-CD) was studied. ASA and FA were complexed at 1: 0.5, 1: 1, and 1: 2 (mass ratio) and dried by freeze drying, solvent evaporation and spray drying. The ASA-hydroxypropyl-β-cyclodextrin (1: 1) complex was prepared by spray drying and compared with the best FA complex. Place all complexes and ASA in a labeled aluminum blister pack and store in a stable dark box at a temperature of 40 ± 2 ° C and a relative humidity of 75% ± 5% for 120 days. The salicylic acid content of each sample was analyzed at 0, 30 d, 60 d, 90 d and 120 d, respectively. The SAA content in the ASA-FA spray-dried complex complexed in a molar ratio of 1: 1 was 4.31%. The complex had the best stability among the complexes of all the different preparation methods. However, the salicylic acid content measured in the 1: 1 ASA-hydroxypropyl-β-cyclodextrin spray-dried complex was only 2.35%. Compared with FA, ASA and hydroxypropyl-β-cyclodextrin complex, its stability is stronger. To improve the stability of aspirin, a new FA complexing agent was studied. Compared with the 1: 1ASA-FA spray-dried complex, the stability of ASA is significantly improved when ASA is complexed with 1: 1 hydroxypropyl-β-cyclodextrin.