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目的观察肾病患者应用不同类型抗生素的实际疗效,分析总结更为科学的临床用药方案。方法选取2010年7月至2013年7月,本院肾内科收治的368名急性肾小球肾炎轻度肾功能不全伴感染患者,经筛选后剩余110名符合相应条件者参与此次临床研究。将110名患者随机分成对照组和实验组。对照组患者按照急性肾小球肾炎标准治疗,实验组除采用同对照组一致的治疗方案外,加用相应的抗菌药物,总疗程8周。结果实验组患者较对照组患者临床症状消失快,肾功能恢复情况更好,仅2例患者出现抗生素性肾损伤。结论急性肾小球肾炎伴感染患者,早期合理使用抗菌药物对于治疗和预后有明显效果,有一定临床价值,但是治疗过程中需要慎重选择抗菌药物,避免滥用药物加重肾脏损伤。
Objective To observe the actual effect of different types of antibiotics in patients with nephropathy and to analyze and summarize more scientific clinical drug regimens. Methods From July 2010 to July 2013, 368 patients with mild renal insufficiency associated with acute glomerulonephritis admitted to our hospital were enrolled in this study. 110 patients were randomly divided into control group and experimental group. Patients in the control group were treated according to the standard of acute glomerulonephritis. In addition to using the same treatment as the control group, the corresponding antibacterials were added in the experimental group for a total of 8 weeks. Results Compared with the control group, the clinical symptoms disappeared and the renal function recovery was better in the experimental group than in the control group. Only 2 patients had the antibiotic-induced renal injury. Conclusion In patients with acute glomerulonephritis, the rational use of antibacterial drugs in early stage has obvious effect on the treatment and prognosis, and has certain clinical value. However, antimicrobial drugs should be carefully selected in the course of treatment to avoid the abuse of drugs and aggravate the renal damage.